Butyrate produced by intratumoural F. nucleatum inhibits HDAC3/8 activity in CD8+ T cells, leading to increased H3K27 acetylation at the TBX21 promoter, which suppresses PD‐1 expression and enhances anti‐PD‐1 therapeutic efficacy in CRC.19 Here, CD8A is linked to colorectal carcinoma.