AKT1 and melanoma: Signal transduction through the WNT, MAPK, and PI3K/AKT pathways in melanoma cells affects the expression of cell adhesion molecules and peptidases, allowing for extracellular matrix (ECM) remodeling and cancer cell migration (Monteiro, Toricelli, and Jasiulionis 2015; Huntington et al. 2004; Lee et al. 2014; Yao et al. 2019; Hess et al. 2003).