FBXL16 and Alzheimer disease: As shown in Fig. 6A and B, FBXL16 inhibited the activation of astrocytes and microglia in the 3×Tg LV-F16 group compared with the 3×Tg LV-GFP group, suggesting that FBXL16 plays a protective role in suppressing the overactivation of astrocytes and microglia in AD mice.