Interestingly, CAFs, which are intimately linked to ovarian cancer progression [102], are frequently activated by TGF-β [103–105] or Wnt [106] signaling pathways in HGSC and other tumor types, and this process can be driven by WNT7A [83], a LowerT gene belonging to our STRATsig signature. The gene discussed is TGFB1; the disease is ovarian carcinoma.