Fuzi, Zhigancao, and Ganjiang are the three ingredients of sini decoction (SND), a traditional TCM remedy found in "Shang Han Lun." To treat CRC, SND extract can increase the expression of CD8+ T lymphocytes and occludin in the colonic mucosal layer while inhibiting the expression of CD4+ T cells and TNF-α, IL-6, IL-17, and IFN-γ in CRC tissue. The gene discussed is TNF; the disease is colorectal carcinoma.