F.nucleatum inhibits the cGAS-IFN-β pathway, decreases the production of Th1 chemokines CCL5 and CXCL10, and downregulates the chemotactic and activating function of CD8+ T cells by secreting the metabolite succinic acid, which stimulates the SUNCR1-HIF-1α-EZH2 axis of the succinic acid receptor in tumor cells. Here, CGAS is linked to neoplasm.