Among the most significant upregulated genes were plakophilin-2 (PKP2), which has been described as a Wnt/β-catenin target in colon cancer CAFs [22], and TIMP metallopeptidase inhibitor 3 (TIMP3), which was also highly upregulated in ovarian cancer CAFs [23]. The gene discussed is TIMP3; the disease is malignant colon neoplasm.