For example, individuals carrying a loss-of-function mutation (rs200185429; p.Arg138* allele; c.412C > T) in ZNT8 have reduced ZNT8 expression in β-cells due to haploinsufficiency of ZNT8 that confers a significant protection (53%) against T2D [13, 14]. Here, SLC30A8 is linked to type 2 diabetes mellitus.