Furthermore, we examined the expression of several CREB target genes (Myc, Sky, Abcg1, and Clcf1), known for their involvement in ADPKD pathogenesis (Booij et al, 2017; Lee et al, 2020; Liu et al, 2019; Pandey et al, 2011). The gene discussed is TYRO3; the disease is autosomal dominant polycystic kidney disease.