Previously, 31 variants across 28 T2D risk loci were reported to have sex-specific effects on T2D in a trans-ancestry GWAS, including one variant near TM6SF2 (rs8107974), two variants at GLI2 (rs11688931, rs11688682), and one variant at KCNQ1 (rs2237895) (Mahajan et al, 2018). This evidence concerns the gene GLI2 and type 2 diabetes mellitus.