The identified associations include loci of definitive evidence cardiomyopathy-associated genes (TNNT2, TTN, PLN and BAG3) and colocalize with recent hypertrophic cardiomyopathy (HCM) (for example, TBX3, STRN and MTSS1 (ref. 30)), dilated cardiomyopathy (DCM) (for example, PKD1, STRN, MITF and CDKN1A31) and heart failure GWAS32. The gene discussed is PLN; the disease is heart failure.