Hypoxia-induced expression of VEGFA potentiates the ability of interleukin-10 (IL-10) and prostaglandin-E2 (PGE2) to drive expression of Fas ligand (FasL) on tumor ECs to selectively induce apoptosis of cytotoxic T cells but leave Treg cells unscathed [88]. The gene discussed is IL10; the disease is neoplasm.