For example, activating mutations of the gene encoding epidermal growth factor receptor (EGFR) or KRAS, or rearrangements of the genes encoding anaplastic lymphoma kinase (ALK) or ROS proto-oncogene 1 (ROS1) have led to the oncogene-centric molecular classification of NSCLC [101]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.