Notably, a cluster of ten hub genes—CDK1, KIF11, NUF2, ASPM, CDCA8, CENPF, DTL, EXO1, KIF2C, and ZWINT—emerged as pivotal fibroblast-specific genes potentially involved in the transition from DCIS to IDC. Here, NUF2 is linked to ductal breast carcinoma in situ.