Expression of the LXR ligand producing enzyme CYP27A1, LXR target gene ABCG1 (but not ABCA1) and TLS/B and T cell signatures (MS4A1, CD19, CR2, CD8a, GZMB and CD69) was decreased in tumours compared with non-tumour samples (Extended Data Fig. 11c), suggesting that suppression of the CYP27A1–LXR–TLS/B cell axis might function as a tumour-escape mechanism in human CRC. The gene discussed is GZMB; the disease is neoplasm.