These observations taken together with the American data of Lupus nephritis showing Anti-Ro to be associated with ESRD, in a multivariate analysis, indicate a possible role of Anti-Ro antibodies besides the conventional autoantibodies like anti ds DNA, anti-nucleosome, anti-Ribosomal P and anti-C1q in Nephritis39.In addition, the low levels of housekeeping cytokines like Flt-3, GRO, IL-1RA, IL-8, IL-9, and IP-10 in the same cluster are possible indicators towards a novel group of patients. This evidence concerns the gene CALR and lupus nephritis.