Immunoblot analysis of sorted primary murine B-ALL cells for downstream targets of the BCR-ABL1 oncoprotein revealed that AKT phosphorylation was significantly decreased in B-ALL cells from the BM (Fig. 4A), but not the spleen (Supplementary Fig. 15B), of ANXA2-deficient compared to WT mice. The gene discussed is AKT1; the disease is acute lymphoblastic leukemia.