Induction of BCR-ABL1+ B-ALL (henceforth termed B-ALL), however, led to a significant reduction of GFP+ (BCR-ABL1)+ BP1+ pre-B cells in peripheral blood (PB) (Fig. 1A), as well as survival extension in ANXA2-deficient compared to WT recipient mice (Fig. 1B). Here, ANXA2 is linked to acute lymphoblastic leukemia.