Testing a possible ANXA2-mediated contribution to neoangiogenesis21 to our observed leukemia phenotypes, we found the percentage of CD45- CD31+ EMCN (endomucin)+ endothelial cells to be increased in the BM of ANXA2 KO mice (Supplementary Fig. 11H, I). The gene discussed is EMCN; the disease is leukemia.