Taken together, these data suggest that IGF1 differentially affects signaling in BCR-ABL1+ versus MLL-AF9+ cells, whereby the effect is greatest on BCR-ABL1+ lymphoid compared to BCR-ABL1+ myeloid cells, possibly due to higher expression of IGF1R on B-ALL cells. The gene discussed is MLLT3; the disease is acute lymphoblastic leukemia.