Immunoblot analysis of sorted primary murine B-ALL cells for downstream targets of the BCR-ABL1 oncoprotein revealed that AKT phosphorylation was significantly decreased in B-ALL cells from the BM (Fig. 4A), but not the spleen (Supplementary Fig. 15B), of ANXA2-deficient compared to WT mice. Here, ANXA2 is linked to precursor B-cell acute lymphoblastic leukemia.