Consistent with ANXA2’s role in converting plasminogen to plasmin, plasmin, but not plasminogen or tPA, was reduced in the BM or plasma of healthy ANXA2 KO mice or ANXA2 KO mice with B-ALL compared to the respective WT controls (Fig. 3A–C, Supplementary Fig. 14A–C). Here, ANXA2 is linked to precursor B-cell acute lymphoblastic leukemia.