ANXA2-dependent activation of plasmin also resulted in increased activation of MMP924 in WT, but not ANXA2-deficient MSC, specifically after stimulation with tumor necrosis factor (TNF)α, which is known to be secreted by B-ALL cells19 (Supplementary Fig. 12H). The gene discussed is ANXA2; the disease is precursor B-cell acute lymphoblastic leukemia.