To identify the contribution of BMM-associated ANXA2 to leukemia progression, as suggested by our microarray data, we transplanted WT leukemia-initiating cells into WT or ANXA2-deficient recipient mice using the retroviral transduction/transplantation models of BCR-ABL1-induced CML or B-ALL or MLL-AF9-induced AML1. Here, ANXA2 is linked to acute lymphoblastic leukemia.