ANXA2 and precursor B-cell acute lymphoblastic leukemia: The anti-protease α2-macroglobulin was significantly decreased in healthy ANXA2 KO compared to healthy WT mice (Supplementary Fig. 14F), while there was a trend towards decreased levels of α2-macroglobulin in the plasma of WT mice with B-ALL compared to healthy mice (Supplementary Fig. 14G).