Systemic plasmin administration to mice with B-ALL, which accumulated in the BMM (Supplementary Fig. 13A), however, led to acceleration and a ‘rescue’ of the disease (Fig. 2I), as well as significant reduction of fibronectin in the BM of ANXA2-deficient mice (Fig. 2J, Supplementary Fig. 13B). Here, PLG is linked to precursor B-cell acute lymphoblastic leukemia.