Indeed, treatment of human MSC with TNFα or coculture of human MSC with the BCR-ABL1+ B-ALL cell line SUPB15, which produces TNFα (Supplementary Fig. 14J), and subsequent culture of Huh7 cells in the conditioned medium of these MSC led to increased levels of plasminogen in the conditioned medium of Huh7 cells (Supplementary Fig. 14K). This evidence concerns the gene TNF and acute lymphoblastic leukemia.