Of note, decreased TRIM47 protein levels by CARM1 knockdown were rescued when treated HCC cells with proteasome inhibitor MG132, but not with lysosome inhibitor CQ (Figs. 2F and S2D), suggesting that CARM1 protects TRIM47 protein from proteasome-mediated degradation. This evidence concerns the gene CARM1 and hepatocellular carcinoma.