The biological functions of the 10 genes in tumorigenesis and PCa progression were investigated by literature study, and we chose heat shock protein 90 alpha family class A member 1 (HSP90AA1), enolase 1 (ENO1), dyskerin pseudouridine synthase 1 (DKC1), phosphoglycerate kinase 1 (PGK1) and heterogeneous nuclear ribonucleoprotein F (HNRNPF) for further study. The gene discussed is HSP90AA1; the disease is posterior cortical atrophy.