To verify whether circRNF19A-aa modulates the malignant phenotypes of PCa cells by interacting with HSP90AA1, we constructed four different types of engineered PCa cells: control cells, linear RNF19A-490aa-overexpressing cells, HSP90AA1-knockdown cells, and linear RNF19A-490aa-overexpressing cells with simultaneous HSP90AA1 knockdown. The gene discussed is RNF19A; the disease is posterior cortical atrophy.