CYP2E1 and neoplasm: The fetal tumor cells exhibited high levels of hepatocyte markers (e.g., ALB), and metabolic markers in the pericentral zone typically activated by WNT signaling (e.g., GLUL, CYP2E1, and RHBG)23 with low levels or absence of various periportal hepatic markers (e.g., ALDOB, PCK1, and FBP1) compared to the normal hepatocytes (Fig. 1b, c and Supplementary Fig. 1c).