TNF and early-onset autosomal dominant Alzheimer disease: The aluminum-exposed group of mice presented increased levels of proinflammatory interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and acute phase reactive protein C-reactive protein (CRP), which indicates that an aluminum-containing diet contributes to systemic inflammatory conditions, as observed in many pathologies, including neurodegenerative disorders such as Alzheimer’s disease.