PFKP and hepatocellular carcinoma: Notably, the Kaplan–Meier survival analysis illustrated the clinical significance of HIF-1A and its downstream genes in HCC patients, as the group with elevated expression of HIF-1A, HK2, ENO2, SLC2A1, PKM, and PFKP, and lower expression of GCK and SLC2A2 was associated with poor prognosis and low survival rate when compared to the counterpart group of low expression (Fig. 5).