The bar graph illustrates a significantly higher gene expression of HK2, ENO2, ENO3, PFKFB3, SLC2A1, and SLC2A2 (Fig. 9g) in the HCC organoids that expressed HIF-1A compared to the organoids with lower HIF-1A expression. The gene discussed is PFKFB3; the disease is hepatocellular carcinoma.