PFKFB3 and hepatocellular carcinoma: In HCC, overexpression of HIF-1A increases the activity of glycolytic enzymes such as enolase 1 (ENO1), lactate dehydrogenase A chain (LDHA), 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 3 (PFKFB3), hexokinases (HK1 and HK2), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), phosphofructokinase-liver type (PFKL), and aldolases (ALD-A and ALD-C) [27].