38). MiR-15a-5p and miR-199a-3p overexpression decreases inflammatory pathway protein levels, such as IKKα, IKKβ, and p65, and it reduces oxidized LDL and NF-κB activation in VSMCs and patients with atherosclerosis (Ref. 39). Moreover, overexpression of miR-340-5p reduces cardiomyocyte apoptosis and inflammation via the HMGB1/TLR4/ NF-κB pathway in myocardial ischemia–reperfusion injury (MIRI) (Ref. 40). The gene discussed is NFKB1; the disease is atherosclerosis.