These shared expression of prostaglandin-related PTGDS and PLA1A with brain-enriched venous ECs (brain_ven_ec), which were also characterized by the G-protein-coupled receptor ADGRL3, and SH3RF3, associated with late-onset Alzheimer’s disease in genome-wide association studies (GWASs)37. The gene discussed is ADGRL3; the disease is early-onset autosomal dominant Alzheimer disease.