CHRM3 and chronic obstructive pulmonary disease: Furthermore, CHRM3 (encoding muscarinic acetylcholine receptor 3 (M3R)) is the target of M3R agonist pilocarpine, used in glaucoma, ocular hypertension and xerostomia, and of antagonists revefenacin and aclidinium bromide, used in chronic obstructive pulmonary disease treatment.