CHEK2 and Infertility: These age-stratified analyses identified three additional GWS loci associated with infertility: two with early-onset infertility near CHEK2 and the major histocompatibility complex (MHC) region on chromosome 9 and one with late-onset infertility, with the lead SNP located in an intron of the long non-coding RNA (lncRNA) gene ENSG00000284418 (Figure S10).