When in vitro anti-tumor activity of NKG2D/Dap10-12, NKG2D-CD3ζ, and NKG2D-CD3ζ/Dap10 CAR T cells was compared using BxPC3 and Ren cell lines, the number of productive tumor re-stimulation cycles (Figure 3D) and cytokine production (Figures 3E and 3F) tended to be greater in NKG2D/Dap10-12 cultures. The gene discussed is KLRK1; the disease is neoplasm.