Further investigation of DEGs and mechanisms underlying differences between NKG2D-based CARs is also warranted, examining which signaling motifs with the Dap10 and Dap12 molecules contribute to the enhanced mitochondrial fitness and anti-tumor activity of the NKG2D/Dap10-12 CAR and how these impact on downstream signaling pathways. This evidence concerns the gene TYROBP and neoplasm.