The impaired R/SI balance is indeed consistent with the established transcriptional changes in sepsis: the sepsis-upregulated functions have stronger correlations with increasing SI levels compared to the correlations with R levels (glycolysis, MMPs; e.g., GPI and MMP24), whereas the sepsis-downregulated functions demonstrate the opposite trend (eIF2 signaling, OXPHOS, and MHC class II, e.g., EIF2AK3, NDUFB2, and HLA-DRA) (Figures 3C–3E, S4C, and S4D). This evidence concerns the gene HLA-DRA and Sepsis.