Given that hepatic insulin clearance is decreased in MASLD,22 we also investigated genes involved in hepatic insulin metabolism, i.e., carcinoembryonic antigen-related cell adhesion molecule 1, CEACAM-1, involved in insulin internalization and insulin-degrading enzyme (IDE), but their expression was not altered with fibrosis stage or the presence of T2D (Figures 4E and 4F), nor with BMI. Here, INS is linked to metabolic dysfunction-associated steatotic liver disease.