INS and type 2 diabetes mellitus: Given that hepatic insulin clearance is decreased in MASLD,22 we also investigated genes involved in hepatic insulin metabolism, i.e., carcinoembryonic antigen-related cell adhesion molecule 1, CEACAM-1, involved in insulin internalization and insulin-degrading enzyme (IDE), but their expression was not altered with fibrosis stage or the presence of T2D (Figures 4E and 4F), nor with BMI.