TNF influences immune pathways like T-cell receptor (TCR) and NF-κB in CTCL and HL, promoting proliferation by activating NF-κB and suppressing PER2. 46CRY1 overexpression reduces inflammation by modulating NF-κB and cAMP/PKA pathways, while CRY2 silencing may enhance immune escape in NHL via IL-6 and STAT3.75 This evidence concerns the gene STAT3 and primary cutaneous T-cell non-Hodgkin lymphoma.