The results of the validation of the WARQ obtained through the first telephone interview – in the AR group ‒ with the guardians, when compared with the clinical diagnosis given by a specialist based on the ARIA criteria for AR and confirmed with objective tests for the diagnosis of IgE-mediated allergy (skin prick test and serum-specific IgE) is showed at Table 2. The gene discussed is IGHE; the disease is allergic disease.