Considering that FANC attenuated ox-LDL-induced macrophage attachment onto endothelial cells, and that FANC activated KEAP1-NRF2 system to turn on the expression of HO-1 to suppress the expression of ICAM-1 and VCAM-1, which are pro-inflammatory molecules of endothelium induced by ox-LDL present in hypercholesterolemia, FANC may play the very first step on inhibiting ox-LDL-induced ICAM-1 and VCAM-1 expression in endothelium in vivo to achieve the anti-atherosclerotic effects. The gene discussed is NFE2L2; the disease is familial hypercholesterolemia.