Individuals in the following categories had a higher proportion of VS during the cohort’s time period: male sex, aged 50–59 years, white race/skin color, with ≥12 years of education, initial treatment regimen NNRTI+1INI, initial CD4 lymphocyte count ≥500 cells/mm3, initial VL count ≤100,000 copies/mL, without an active tuberculosis episode, without therapeutic regimen change, with ≥95% adherence to treatment, and receiving clinical follow-up in facilities located in the Southeast or South regions, in metropolitan areas, and in facilities serving >500 PLWHA. Here, CD4 is linked to tuberculosis.