GRN and frontotemporal dementia: Autofluorescent lipofuscin is a marker of lysosome dysfunction and a neuropathologic feature of human FTD-GRN and Grn−/− mouse brain tissue.35,67,68 We set out to evaluate the extent and anatomical location of lipofuscin neuropathology in our rAAV-injected Grn−/− mouse brain cohorts.