The target molecule was identified as HMWoTau with circa 2000 kD as a minimum size and the more oligomerized species (>5000 kD), in combination analysis with Size‐Exclusion‐Chromatography and Sucrose‐Density‐Gradient‐Centrifugation for both recombinant human (rh) Tau‐derived aggregates and AD brain‐lysates in PBS(−). The gene discussed is MAPT; the disease is Alzheimer disease.