One article demonstrated that PBS‐extractable AD brain lysate with high‐seeding activity contained higher levels of HMWoTau than those of moderate−/low‐seeding activity in AD subjects using SEC (Superdex 200 10/300 GL; fractionation range from 10 to 600 kD for globular proteins) and a two‐site sandwich ELISA with the same pan‐antibody HT7 as capture and detector,19 supporting the link between HMWoTau level and tau‐seeding activity on tau‐propagation. This evidence concerns the gene MAPT and Alzheimer disease.