Interestingly, confocal microscopy showed that ZIKV infection induced an accumulation of IGF2BP1, IGF2BP3, and YBX1 in the replication compartment as for IGF2BP2 with partial colocalization with dsRNA and NS3 (Figure 8—figure supplements 1 and 2C, D), which supports that ZIKV physically co-opts an RNP containing these fours RBPs. This evidence concerns the gene RNPC3 and Zika virus infectious disease.