There were significant differences in D2HGDH expression between non-tumour samples (controls) and all glioma subtypes (GB (P = 1.30 × 10−6), astrocytoma (P = 9.00 × 10−7), oligodendroglioma (P = 1.50 × 10−7), mixed glioma (P = 9.40 × 10−3) or unknown histology (P = 2.50 × 10−9)) (Supplementary Fig. S4A and B) [24]. This evidence concerns the gene D2HGDH and central nervous system cancer.