SLC8A1 and central nervous system cancer: Our MR results show that increased SLC8A1 isoform mRNA expression is putatively protective against glioma; however, a previous study found that the cytotoxic effect of amiloride, a drug which kills glioma cells, occurs due to dual inhibition of sodium-proton exchanger (NHE1) and the NCX1.1 isoform, leading to glioma cell demise through increased Ca2+ concentration [62].