We also present novel evidence for a causal effect of increased HBEGF expression in cortex on increased risk of all glioma, novel evidence for causal effects of CEP192, FAIM and SLC8A1 splicing in multiple tissues on variable risk of all glioma and GB and novel evidence for a causal effect of increased protein abundance of D2HGDH in cortex on decreased risk of all glioma in the cortex. The gene discussed is D2HGDH; the disease is central nervous system cancer.