Across the multi-omic analyses, we found robust genetic evidence for five genes that have not been implicated with glioma risk in previous genetic studies: CEP192 (Centrosomal protein of 192 kDa), D2HGDH (D-2-hydroxyglutarate dehydrogenase), FAIM (Fas apoptosis inhibitory module), HBEGF (Heparin binding epidermal growth factor) and SLC8A1 (Solute carrier family 8 member A1). Here, HBEGF is linked to central nervous system cancer.