We found that of the novel molecular traits with robust causal evidence, D2HGDH was suggestively associated with asthma, FAIM was suggestively associated with LDL cholesterol, and SLC8A1 was suggestively associated with allergies and asthma (P < 0.05), suggesting that these molecular trait effects are not independent of reported risk factors. The gene discussed is SLC8A1; the disease is allergic disease.