HERC2 also contains a non‐heme‐binding cyt‐b5 like domain (cyt‐b5, residues V1207–L1283), a Mind‐bomb‐HERC2 domain (M‐H, residues S1859–P1932), and a downregulated in ovarian cancer domain (DOC, residues Q2774–R2914), whose roles and functions remain unclear. This evidence concerns the gene HERC2 and ovarian cancer.