miRNAs primarily interact with the 3′-untranslated region (3′-UTR) of target mRNAs, inducing translation suppression and mRNA degradation.9 miRNAs have been implicated in diverse cancer biological processes, including growth, migration, invasion, angiogenesis, and apoptosis.9,10 However, our understanding of miRNA – mRNA interactions as regulatory module remains limited.11 Particularly, the specific miRNA regulators for PDLIM1 in DLBCL remain unknown. This evidence concerns the gene PDLIM1 and cancer.