Additionally, LBP modulated APP processing by downregulating the expression of BACE1 and upregulating the expression of ADAM10, and inhibited the production of excessive ROS by inducing the SKN‐1‐mediated antioxidant system and FSHR‐1‐mediated mitochondrial unfolded protein response (mtUPR) in a C. elegans model of AD [42, 43]. The gene discussed is LBP; the disease is Alzheimer disease.