The downregulation of pro‐inflammatory markers and upregulation of anti‐inflammatory markers in the brain, spinal cord, and retina suggested that LBE switched the microglial phenotype in the CNS (brain, spinal cord, and retina) from pro‐inflammatory(iNOS+) to neuroprotective (Arg‐1+), which may contribute to delaying AD pathology. The gene discussed is NOS2; the disease is Alzheimer disease.