Likewise, deficiency of KMT2D sensitizes HCC cells to cisplatin with severe arrest of cell viability (Figs. 5E and S5D), elevated expression of γH2AX (Figs. 5F and S5E), γH2AX foci (Fig. 5G), and cell death (Figs. 5H and S5F). Here, KMT2D is linked to hepatocellular carcinoma.