Reduced energy availability, detected by the hypothalamus, triggers endocrine shifts, decreasing LH pulsatility and causing reproductive issues (anovulation, oligomenorrhoea or amenorrhoea).50 51 REDs can result in health complications, including a high injury risk rate, chronic fatigue, etc.52Therefore, our values may facilitate on-field applications to identify potential hormonal changes during elite athletes’ follow-up. The gene discussed is PLOD1; the disease is anovulation.