NF2 and meningioma: Studies have found that the abnormal mutation of merlin in meningiomas, which can increase the activity of CRL4 as NEDD8 E3 ligase, may promote the binding of CRL4 and its specific substrate protein DDB1 And CUL4 Associated Factor 1 (DCAF1), induce the mimicinization of DCAF1, and then promote the proliferation of meningioma cells (Angers et al., 2006).