The results of another trial on the combination of TMZ and MLN4924 in the treatment of GBM also showed that the combination of TMZ and MLN4924 can inhibit MGMT-mediated DNA repair by enhancing p53-mediated MGMT inhibition and may be responsible for the increased sensitivity of GBM to TMZ (Brandt et al., 2023). This evidence concerns the gene TP53 and glioblastoma.