When assessing the associations between SSc disease-specific, demographic, and cardiovascular parameters with CRP positivity, we found that suffering from type 2 diabetes mellitus increased the risk of having a prolonged CRP−positive status by 5.3-fold (OR: 5.25 [0.87–31.52] p = 0.070) (Table 2). This evidence concerns the gene CRP and type 2 diabetes mellitus.