In a recent population-based cohort study, Kurmann et al. (37) demonstrated that for SSc patients in general (no stratification by CRP status yet), the real-world 10-year-risk for suffering a cardiovascular event was 5 times higher than what was predicted by their respective ASCVD risk scores (37), concluding that the currently recommended ASCVD risk calculator heavily underestimates the ASCVD risk in SSc. The gene discussed is CRP; the disease is systemic sclerosis.