Acquired demyelinating syndrome (ADS) comprises a spectrum of monophasic and recurrent inflammatory conditions of the central nervous system (CNS), such as acute disseminating encephalomyelitis (ADEM), neuromyelitis optic spectrum disorders (NMOSD), multiple sclerosis (MS), and clinically isolated syndromes, myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD) (1). Here, OMG is linked to myeloid sarcoma.