SPINK1 and pancreatitis: What is noteworthy is that genetic factors also play a significant role in predisposing individuals to pancreatitis, with mutations in the PRSS1 (protease serine 1), SPINK1 (serine peptidase inhibitor Kazal type 1), CFTR (cystic fibrosis transmembrane conductance regulator), CTRC (chymotrypsin C), TRPV6 (transient receptor potential cation channel subfamily V member 6), and CPA1 (carboxypeptidase A1) genes being predominant contributors (18, 19).