BCL2 and cancer: The mitochondrial signaling pathway is implicated in the liberation of Cyt C and proteins inducing mitochondrial apoptosis through the Bcl-2/Bax axis, thereby initiating subsequent phases of apoptotic mechanisms (Kao, 2017, Irizarry Rovira, 2018, Trotta and Chipuk, 2017) Consequently, Cyt C may play a part in the initiation and advancement of cancer.