The link between TREM2 and DAM progression in AD is strongly outlined in a way that remains unparalled by other neurodegenerative diseases, though recent studies have shown TREM2 to be associated with PD and MS pathology, making it a promising marker to explore (Guo et al., 2019, Rayaprolu et al., 2013, Cignarella et al., 2020). This evidence concerns the gene TREM2 and Parkinson disease.