With the variety in known etiologies and widely used pathogenesis triggers for PD including genetic, environmental, and α-synuclein fibril seeding, it becomes pertinent to consider technologies such as cellular indexing of transcriptomes and epitopes sequencing (CITE-seq) or assay for transposase-accessible chromatin (scATACseq) in a longitudinal investigation across these varying models. The gene discussed is SNCA; the disease is Parkinson disease.