Current understanding of DAM in PD has come from PD pathology induced by α-synuclein via AAV transduction (Schonhoff et al., 2022) in which neuroinflammation precedes neurodegeneration, but investigation in other models and in post-mortem human PD tissue could yield a more nuanced understanding of DAM (Garcia et al., 2022). The gene discussed is SNCA; the disease is Parkinson disease.