DDIT4 and Hepatic fibrosis: In non-alcoholic fatty liver disease, liver fibrosis, methionine-choline-deficient diet induced steatotic liver injury, bile duct ligation surgery induced cholestatic liver injury, and in CCl4 injection induced hepatotoxic injury, abnormal increase in DDIT4 expression (Dumas et al., 2020; Cho et al., 2021; Li et al., 2021).