The level of Mex3a promoter methylation exhibits negligible correlation with gender (p = 0.667), HBeAg (p = 0.586), AFP (Ng/mL) (p = 0.907), primary tumor number (p = 0.817), tumor size (p = 0.265), lymph node metastasis (p = 0.858), distant metastasis (p = 0.420), vascular invasion (p = 0.328), CTP staging (p = 0.648), BCLC staging (p = 0.237), or encephalopathy (p = 0.079). The gene discussed is AFP; the disease is neoplasm.