As shown in Table 5, all data indicated that male gender (OR = 0.342, 95% CI 0.212–0.550, and p < 0.001), PMR value of the Mex3a promoter>0.824% (OR = 0.189, 95% CI 0.113–0.316, and p < 0.001), Mex3a mRNA level <9.005% (OR = 0.035, 95% CI 0.020–0.062, and p < 0.001), AFP< 20 ng/mL (OR = 0.267, 95% CI 0.160–0.447, and p < 0.001), and HBV-DNA positivity (OR = 1.708, 95% CI 1.031–2.828, and p = 0.038) were independent risk variables that had an impact on the development of HCC linked to HBV. This evidence concerns the gene MEX3A and hepatocellular carcinoma.