The function of HSP90 and the impact of HSP90 inhibitors in the most popular kind of lymphoid malignancies, such as diffuse large B-cell lymphomas (DLBCL) that come from germinal center B-cells, remain largely unexplored and not well understood (Klein and Dalla-Favera, 2008). The gene discussed is HSP90AA1; the disease is diffuse large B-cell lymphoma.