Wang et al. (2015d) discovered that miR-421 is involved in suppressing the translation of Pink1, leading to myocardial infarction, apoptosis, and mitochondrial fragmentation by decreasing Pink1 expression, a serine/threonine kinase that targets mitochondria and inhibits cardiomyocyte apoptosis (Siddall et al., 2013). The gene discussed is PINK1; the disease is myocardial infarction.